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pentobarbital will decrease the extent or impact of guanfacine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Potent or reasonable CYP3A4 inducers appreciably decrease guanfacine plasma concentrations and elimination 50 %-existence.If your dose in the concomitant CYP3A4 inducer can not be decreased or disc